RPC over HTTP stops working over time

We've got a weird situation happening on a backend Exchange cluster. Here is a our Current setup:

Front end in DMZ
2 backend clusters Cluster01, Cluster02 behind firewall
Cluster01 has 4 nodes Node A and B are a pair and Node C and D are a pair

The active node of Cluster01 pair C and D Intermittently loses the ability for RPC over HTTP but a fail over fixes the issue. Those same users can still use OWA. Users on Cluster01 A and B pair have no problem nor does Cluster02 with rpc over http during the same time that cluster01 pair C and D are having problems. So it's narrowed down to node pair C and D but I'm not sure where to go at this point.
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regmoviesAsked:
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ATIGConnect With a Mentor Commented:
Please look over my blog on Outlook Anywhere I know its related to EX 2007 however from Ex 2003 sp2 there want not any change in the way it works.

http://exchange-genie.blogspot.com/2008/02/configuring-outlook-anywhere-for.html

It will walk you through some troubleshooting with rpc diag,

basically the mbx server makes referals to its self and calls to DC/gc's so it could be any number of issues.

You also stated a failover fixes this, if you fail back to the affect nodes does it work again?

have you checked the event logs, have you checked to a memory leak etc?
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