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Outboud messages sit in Queue with the following error 451 4.4.0 primary target IP address responded with "421.4.4.2 unable to connect."

Posted on 2008-10-22
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Last Modified: 2013-11-30
I have just installed Exch2007 and am having problems with sending mail.

Messages just sit in the queue with the follwoing error message:

451 4.4.0 primary target IP address responded with "421.4.4.2 unable to connect."attempted failover to alternate host, but that did not succeed.Either there are no alternate hosts, or delivery failed to all alternate hosts.

Any ideas what is wrong or what I shoudl be checking?

Incoming mail is fine.

Exchange 2007 SP1
Server 2008 x64
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Question by:grahamsmyth
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by:marques_salazar
ID: 22781889
Are you getting event id 2019?
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by:marques_salazar
ID: 22781909
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by:grahamsmyth
ID: 22784306
I don't see that event coming through.

I have attached a copy of the event log.
System-Events.txt
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grahamsmyth earned 0 total points
ID: 22800183
Managed to figure it our - Transport Service would not start due to IPv6 being disabled!!!
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