This problem only happens on one of my terminal servers. Everywhere else all is fine.
When opening an excel document from the companyweb we get this message. "The operating system is not currently configured to run this application" When you click OK the document opens in read only mode outside the browser window. It opens's line a normal Excel file but in read-only mode.
Re-installed Office, re-applied SP3, verified all user security, RDP settings and local GPF are the same as on the system that works.