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Flash runtime error with USB external disk: virus or malware or hardware fault?

WHen I connect up my USB external disk to my Thinkpad, the Thinkpad (with uptodate PCCilin)
can't detect it  from Explorer though a message pops up at the right bottom corner that says
"Samsung HD300" detected

WHen I connect it up to my Dell Inspiron 6400, takes a while & then a message "Flash
runtime error) & the Dell rebooted.

How can fix this or determine if it's virus/malware or hardware fault?

Quite a lot of data in it
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sunhux

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I right-click on My Computer, click Manage &
under Storage, click "Disk Management" & it
took about 1 minute showing "Connecting to
Logical Disk ... Manager"

I: drive appeared to the external USB disk, showing
as "Disk 1", "279.46Gb Online but Explorer still can't
see it, neither could I access it from MSDOS prompt.

How do I copy it from Disk Management?

I'll attach a screen dump shortly
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Attached the  Flash 'run-time error 53'  &  "Disk Management" screen dumps
USBDiskerrscrdmp.JPG
DiskMgtUSBscrdmp.jpg
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At MSDOS prompt, the error I got is :

C:\> dir i:
The request could not be performed because of an I/O device error.
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http://www.pcaholic.com/blog-computer-chat/runtime-error-53/
tells me to 'uninstall' but what do I uninstall?  So I've downloaded
from the above link a "Driver Detective" tool instead but when I run
it, it asks for Registration & sort of licence key. So did not progress
further with Driver Detective

I've downloaded devcon, unzip it (by running the .exe downloaded) &
run the command
"devcon enable @usb\* "  :

Should I reboot my Dell Inspiron 6400 first.  Anyway, before rebooting,
tried accessing & got a a different error this time

C:\devcon\i386>devcon enable @usb\*
USB\ROOT_HUB\4&10D90B96&0                                   : Enabled
USB\ROOT_HUB\4&2263344D&0                                   : Enabled
USB\ROOT_HUB\4&27A8915E&0                                   : Enabled
USB\ROOT_HUB\4&3932BA15&0                                   : Enabled
USB\ROOT_HUB20\4&1A83CD01&0                                 : Enabled
USB\VID_04B3&PID_3107\5&18BD802A&0&1                        : Enabled
USB\VID_12D1&PID_1003\5&1BB9C9F4&0&1                        : Enabled
USB\VID_12D1&PID_1003&MI_00\6&35F0F58&1&0000                : Enabled
USB\VID_12D1&PID_1003&MI_01\6&35F0F58&1&0001                : Enabled
USB\VID_12D1&PID_1003&MI_02\6&35F0F58&1&0002                : Enabled
10 device(s) enabled.

C:\devcon\i386>dir i:\
The volume does not contain a recognized file system.
Please make sure that all required file system drivers are loaded and that the v
olume is not corrupted.


What do I do next?
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After rebooting the Dell Inspiron 6400, with the USB disk connected, the Dell
stops & freezes with all its LEDs'  lights off.  Have to pull out this disk & the
Dell continues booting & presented the login screen.

Btw, I've also done the USB reset below :
rundll32.exe setupapi,InstallHinfSection DefaultInstall 132 C:\WINDOWS\inf\usbstor.inf
& connect up the USB disk & it still gave the "Run-time error 53" once the disk is plugged in"

I recalled I was able to use Acronis boot CD to boot up & take image backup this Dell
(& my brother's Dell notebook as well) to this external USB disk.

So I decided to try this time :
Acronis boots up while USB disk is connected & in the main screen, Acronis could
detect this disk but when I tried to backup a small partition on the Dell to this disk, it
freezes.  I then tried to backup this USB disk to my Dell's local disk & it displays a
message "there may be a problem with this disk & it could only be backup sector by
sector".  Then Acronis freezes too while attempting to read this USB disk.

The Acronis boot CD has the latest drivers & was working previously with this same
Dell & the this USB disk.  Since Acronis does not start up Windows at all (it's sort of
a Linux miniOS),  can we safely conclude there's a problem with this disk & not my
Dell?

To be prepared for the worst eventuality, anyway I could copy out the data from
this USB disk?  I've heard of professional recovery services (of bad/crashed disk)
 but if anyone here can tell me how to do this, appreciate it.
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