NT Backup errors

I seem to be running into trouble with some of our servers running NT backup.  Every time one of the scheduled full backups run there seems to be a problem.  It will run for a few hours and then it won't successfully complete.

Error: The device reported an error on a request to write data to media.
Error: C: is not a valid drive, or you do not have access.

I am also getting a code 1f

The differentials are working just fine and are being backed up at the same location.
bkort1Asked:
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MiniDevoCommented:
What brand/type of server are you running? I'm seen Dell PowerEdge servers pop up with this type of tape drive error, but only in Windows Server 2003.
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QlemoBatchelor, Developer and EE Topic AdvisorCommented:
Are you backup on tape or disk? There are bugs using disk targets in combination with (file system) compression, when reaching 40 GB.
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bkort1Author Commented:
We are backing up on disk.  When what reaches 40 GB?  The disk that we are backing up on?
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QlemoBatchelor, Developer and EE Topic AdvisorCommented:
The resulting file
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QlemoBatchelor, Developer and EE Topic AdvisorCommented:
The resulting file's uncompressed (!) size, to be precise.
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bkort1Author Commented:
Actually I am running a full backup right now, on one of the ones that failed last time, and it looks to be about 31 GB when it is done.  What can be done here?
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QlemoBatchelor, Developer and EE Topic AdvisorCommented:
Ok, so we have to follow another branch ... Does your eventlog tell you more about IO failures?
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