ASPNET AJAX Fails to load on Page Refresh

I am using ASPNET AJAX, VS2008, Framework 3.5. I have ASPNET AJAX working fine in many places. I have a page which has several AJAX controls on it all of which work fine, except when the page is refreshed (via F5) it gives the infamous 'ASP.NET Ajax client-side framework failed to load'. The usual fix doesn't work because I already have AJAX working its not a web.config issue. I'm stumped any ideas would be welcome.
schmidlopAsked:
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tiagosalgadoCommented:
Maybe you want to see if any suggestion at this site would help you.
http://stackoverflow.com/questions/75322/sys-is-undefined 
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schmidlopAuthor Commented:
Turns out that Vista (IIS 7) was the cause of the problem this blog was what helped me solve the problem
http://blogs.telerik.com/AtanasKorchev/Posts/08-07-18/Web_Resources_demystified_Part_3_Troubleshooting.aspx

I was missing this:

<handlers>  
<add name="ScriptResource" preCondition="integratedMode"  
verb="GET,HEAD" path="ScriptResource.axd"  
type="System.Web.Handlers.ScriptResourceHandler, System.Web.Extensions, Version=3.5.0.0, Culture=neutral, PublicKeyToken=31BF3856AD364E35" />    
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schmidlopAuthor Commented:
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