Microsoft Update sites are blocked on my office Machine - How can I resolve this?

all Microsoft Update sites seem to come up with a message that they are inaccessible??
Pls Hlpe me resolve this?
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Can you be more specific, post an error code?
Try the folowing solution:
1.      In Internet Explorer, click Tools, then click Internet Options. (Alternatively, you can click Start, click Run, type inetcpl.cpl, and then click OK.) The Internet Properties dialog box appears.

2.      Click the Security tab.

3.      In the Select a Web content zone to specify its security settings box, click Trusted sites, and then click Sites.

4.      In the Trusted sites dialog box, clear the Require server verification (https:) for all sites in this zone check box.

5.      In the Add this Web site to the zone text box, enter, then click Add.

6.      Click OK.

7.      Click OK again to exit the Internet Options dialog box.
flamsfAuthor Commented:
Server Error in '/' Application.

The resource cannot be found.
Description: HTTP 404. The resource you are looking for (or one of its dependencies) could have been removed, had its name changed, or is temporarily unavailable. Please review the following URL and make sure that it is spelled correctly.

Requested Url: /microsoftupdate/v6/default.aspx

Above comes on the screen even after trying previous steps just described - no change even after re-boot.
flamsfAuthor Commented:
ABove was caused by Trojans which changed DNS.
Resolved by running free download anti malware from Malwarebytes

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