User profiles are being overwritten when loogin to the the Domain

The Company runs a single Domain Controller, a single Exchnage server and a few data/application servers.
Some of the users noticing that their Profiles are being overwitten and that the problem is intermittent, Beside Group Policy that may prohibit them from changing their profile
1.  what else could be the cause for this problem ?
2.  Where would you look
3.  What would you recokmend to do to resolev the issue
jfk1959Asked:
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stehardy88Commented:
What OS are you running? It's a known problem on Windows 2000 with profiles duplicating (see: http://support.microsoft.com/kb/314045).

We suffer a simular problem on our domain, narrowed it down to a problem with Outlook 2003 not closing properly.
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stehardy88Commented:
Fix:

Whilst users are NOT logged go to:

HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows NT\CurrentVersion\ProfileList

Find the key relating to the user and change ProfileImagePath from %SystemDrive%\Documents and Settings\User.DOMAIN.000 back to %SystemDrive%\Documents and Settings\User

(Note: this can be done remotely by loading RegEdit going to File and Connect to Network Registry) *assuming you have admin rights to network PC*

Microsoft have fixed this issue in XP - if it duplicates it creates a TEMP profile which is used for that session, but the original profile is restored after a reboot.

Therefore best fix is to upgrade to XP if possible If not then you could try using the tool UHCP Clean.
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