How can I get space back on C drive svr 2000

You will need to look at what is on the driver and clean it up your self.  Only you can really decide what is needed and what is not needed.

Is there another drive on the server that you can move things to?

If you think that SAV is not working properly, you might try to uninstall and once that's done manually clean up the SAV folders.  Then reinstall.

Is Windows installed in that partition? Look in the Windows directory, and as long as you have "Show Hidden Files and Folders" option enabled, you should see a list of folders similar to this:

$NtUninstallKB123456$

There will be quite a few of them (one for every update you've installed) including a few for Services Packs. You can safely delete all of these folders if you need to free up space. All they are is the uninstall information for these updates.

Check out this excellent page on how to free up space on c.
http://www.lwcomputing.com/tips/static/bootdrivesize.asp

Thanks navdhanjal...that helped somewhat.  However, the main problem seems to stem from a recent Symantec update.  I may not be wording this right but does anyone know if its safe to delete older .vdb files found in the Signatures folder of Symantec?  Seems we have a lot of .vdb files (or files associated with it) taking up space.

If the server still refuses to update, you can manually download the Antivirus definitions from the Symantec website, and apply them - this will sometimes work where Liveupdate doesn't.

I've had occasions where I've done this and its gotten everything flowing again, fixing LiveUpdate in the process (it updates all new defs properly after the initial manual update I do)

That did the trick! Thanks very much for your help.

You might also want to check my web page for additional ideas:
http://www.lwcomputing.com/tips/static/bootdrivesize.asp