I purchased Bose Companion 2 Series II speakers, but they don't work on either of two new Vista machines (both purchased in the last 3 months).
Setup appears normal and easy. On the back of each PC are six connectors (3x2) plus one red connector at the bottom called "Digital audio". No matter which connection I plug the speakers into, there is this very loud humming nosie, like at a conference meeting when the speaker is turned on and it drives everyone beserk.
I stopped by Best Buy where I purchased it, they said bring it in, but he did say the "Digital audio" button was the right one.