I guess my not yet born son would hope his anonymous mother's genetics would prevail, or he can accept the possibility of the disease of his grandfather in order to have life and 75+ good, healthy years.

And I hope that your good genetics will combine with the good genetics of the mother to produce a very healthy boy.

would you know how genetics and obesity are related?
dominant?

>> would you know how genetics and obesity are related?

Obesity is a complex condition resulting from genetic, cultural, and individual variation.  Probably no simple answer.

     http://www.wrongdiagnosis.com/artic/understanding_adult_obesity_niddk.htm#genetic

the surrogacy clinic told me the donor's records include all medical and bio-data on the parents and grandparents, so if obesity, etc was there it will be detected.

1. Not all traits are 100% deterministic by genes
2. Not all those 100% determined by genes are determined by a single gene on one chromosome
3. The current science is not able to find the genes, or other causes, for all diseases
4. If I could give you the complete list as you requested, I would have won all the Nobel Prizes for the next 100 years, at least.
5. But I can bet safely and win(!) that your father won't have even a single grandkid with blue eyes if the kid's maternal family line has never had anybody with blue eyes, even if all your father's kids had perfect blue eyes!!!
6. Tell your father's 3rd brother to take it easy. He usually can have half the diseases his brothers have, instead of all of them -- only half of the genes of two brothers are shared -- if they have the same biological parents.
7. If you want your kids to be slim, raise him/her up in a country where most people are slim. Eat their diet, and walk their streets instead of drive around in a car all the time.

so my father having blue eyes, and my sister and i having my mother's brown eyes, won't yield any grandkids with blue eyes? Unless there are ENOUGH grandkids?
1 grandkid maybe blue eyes?
2. probably one would?
3 most likely one would?
etc.

Assuming blue eyes are determined by 1 gene. Each gene can have two physical copies. Your father has two recessive blue eye gene copies. Assuming your mother has two brown eye gene copies. (She might have 1 brown and 1 blue, but in that case, half of your siblings would have blue eyes, which is not the case.) Then all your siblings and you have 1 blue and 1 brown. If you can find a blue-eyed mother for your kid, then your kid will have 1/2 chance of having blue eyes. If the mother is just like you with only 1 blue-eye gene, the the kid will have 1/4 chance of having blue eyes. This is an over-simplified calculation that can be used a guideline. If your father have dominant traits that have been passed along to you, then the grandkids will have >= 1/2 chance of inheriting those traits. It is >= 1/2, because there is a chance that your mother would also contribute a copy of the same gene. All above discussions are based on the single-allele, dominant/recessive inheritance patterns.

The most common skip generation traits are those linked to the X-chromosome, or Y-chromosome. Genetic predication is quite simple if you understand the underlying principles. My undergraduate major was Genetics and Genetic Engineering and I have been a researcher in the area for several years.

ok, thanks, I knew of dominant and recessive so didn't realize the blue eyed gene can be hidden and can stay hidden for a while, (and if the subsequent kids and their spouses having brown eyes, and grandkids having all brown eyes could make the lonely blue of my father become even more recessive I guess. I am not sure of the eye colors of my grandparents or the eye clolor of my fathers 3 brothers or my mother's sister. Interesting subject to me, genetics in general.
Glad you could comment and wish you had been abe to be in on the original commenting.

I'm going to be a parent thru surrogacy and egg donorship and the profiles will have all bio data and medical records for the egg donor, and her parents, not sure about grandparents, same for the surrogate. Not sure what diseases, etc. I could look for, that skip or are recessive. I guess after some research on these women, I'll have to possibly not worry about disease and genetic defects. Eye color etc will not be an issue.
I will be in the Chromosome hunt, X and Y, since a specialist will combine them in some way to 99.9% guarantee a male child.

Thanks...................