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Exchange 2007 Extremely High RPC

Our Exchange 2007 installation is having major performance problems.  Outlook 2007 just sits and hangs for people, delays when typing, even crashes.  Exchange Troubleshooting Assistant shows Extremely high RPC user activity anywhere from 25 to 75 - not .25 but actually 25, but we can't find the source of this.  Have tried disabling our spam/virus scanner.  Where else should we look?

Running SBS 2008, Symantec Mail Security for Exchange, 15 users, High end Dell server
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Mestha
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Remove the Symantec software, disabling it is not enough. Then reboot the system.
Anything else accessing the server? Blackberry for example?
Do the users have desktop search installed? Are they in cached mode or live?
How is the storage configured?

Simon.
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sebesta

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Blackberry Enterprise is Running on another server.  Some users have windows live search and Google Desktop search.  I have disabled it for the users with larger mailboxes.  I switched the large mailbox users (there are two of them( from cached mode which just sat at "updating contacts" continuously to online mode, which for a little bit was a big improvement but now runs just as poorly.  Storage is 5 147GB 15k RPM drives in a RAID 5, Standard SBS 2008 setup (all on one parttition), except that I have moved the Exchange databases to their own partition.  Thanks.
You might want to consider Client Throttling if desktop search is causing problems.

http://technet.microsoft.com/en-us/library/cc540454.aspx

Also are all clients Outlook 2007 ?
Lots of things there...

BES - for each BES user that is equivalent to between 4 and 5 additional users on the system. So if you have 10 BES users then that could provide an equivalent load of 50 additional users.

Out of cached mode means everything is running live, which can include things like desktop search. Desktop search can increase the load significantly.

However your hard disk configuration is going to be a major bottleneck. RAID 5 isn't the fastest anyway, and an Exchange system ideally should have two arrays not one. Using partitions doesn't help in anyway, it needs to separate physical partitions.

Simon.
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We have 6 Blackberry users, about 15 local users on exchange, and about another 20 using OWA.  The server is a new Dell, dual quad-core processors, 8 GB memory, 5x 147GB 15k RPM drives so I would think performance for that many users shouldn't be a problem.  All of the disk performance numbers are borderline but pretty much normal.  The RPC count is the one that's sky high.  Is there a way to monitor the RPC requests to see where they are coming from?
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Mestha
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Still trying to find the source of our sluggishness.  BitRunes is a useful tool since Exmon isn't available for Exchange 2007.  Thanks.