Exchange Sending mAIL pROBLEM

I am receiving the beolow error maessage when someone emails a specific domain.  However, I am not blocking anything,

You do not have permission to send to this recipient. For assistance, contact your system administrator.
  < #5.7.1 smtp;554 5.7.1 <>: Relay access denied>
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Stephen CroftConnect With a Mentor Technical ArchitectCommented:
Is your server on black lists? Did you checked this?
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