The first signs are that the Outlook signatures contains html garbage, the users cannot print from Outlook unless they change the email to plain text, eventually the user cannot get to the Microsoft.com website for updates. After that, the virus starts infecting .exe files and throws DEP errors constantly. We have had a fix from Symantec that finds the .exe files, but it quarantines them and of course, the worse the computer is, the more likely the computer is fried. We have cleaned several files on our file server, but it can get reinfected every time someone accesses it. This is a bad one. We have Symantec working on it, Sunbelt working on it, but we fear that we may have to reimage 150 machines as that seems to be the only fix right now.