Have a system where the process DWM is using so much of the CPU that nothing else will really run. Once the system is booted, if you startup IE it'll take 5 minutes to load.
Also, when booting the system into Safe Mode, after the Dell splash screen appears, after pressing F8 the lines of text for the boot options and when the system is loading the drivers the lines of text take about 2 seconds/line to draw.
I ran AVG in SafeMode. It didn't find anything.
I pulled the drive and have it connected to another system. Ran AVG again: Clean. Windows Defender: Clean. About to run Spybot.