IE spam popup

My antivirus gave me an error while surfing the internet the other day.  Afterwards my IE homepage was changes as well as my default search engine, and a tool bar added to IE.  The toolbar and search engine was  I uninstalled the toolbar and fixed my homepage and search engine, but now about three times a day a IE window pops up and shows an advertisement.  It usually says media.fastclick.... and then goes to another page.  I have ran a few spyware programs and nothing is being reported.  I have tried windows defender, and LopSD.  I have attached a hijackthis log.  What should be my next step?
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cracksalsaConnect With a Mentor Commented:
Try running malware bytes. It seems to catch alot that others don't.
I would like to add..

After you scan with malwarebytes.

Download -->

It will fix your IE back.

I hope this helps
JDominguezNYConnect With a Mentor Commented:
I looked through your HijackThis log and noticed a couple things you could fix up.

First off I would delete the file:

This executable is also know to get into your registry so I would check the following locations for abnormal entries:
HKCU\Software\Microsoft\Windows\Current Version\Run
HKCU\Software\Microsoft\Windows\Current Version\RunOnce

I would also check off and let HijackThis fix any issues where it has listed as (file missing)
If you are looking in to blocking these types of ads and  pop-ups, have a look at this website on some great ways to configure you browser and other applications.
Look under Browser Configuration and it will help you setup your Browser.
Hope this helps.
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