POP3 550 5.7.1 Error

I have enabled POP3 on my exchange server which works perfectly internally.  I have opened the necessary port 110 on the Firewall and can telnet to port 110 from an external source.  From the outside using Outlook I pass all tests and have a checkmark where my outgoing server requires authentication is located.  I can pull down messages but can not send to an external domain.  Any Help?
tdn9999Asked:
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MesthaConnect With a Mentor Commented:
Port 110 is for POP3 only, when you are sending email it uses SMTP.
The authentication settings for SMTP need to be set specifically, and in the format of domain\user.

Although if this is Exchange 2003 or higher, why are you using POP3 anyway? Awful protocol. Preferred remote access solution is RPC over HTTPS/Outlook Anywhere.

Simon.
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tdn9999Author Commented:
FYI...

My Exchange SMTP Relay Access is set to allow all computer which successfully authenticate to relay
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