Layer 2 Connectivity Issue.

I have a switch which won't allow me ping a management station.   This computer worked perfectly well before it was removed for a virus cleanup. Nothing has changed on the switch or switches!  It is a 3750 switch and both the management station the unreachable computer are all on the same vlan but on different switches across the network. The computer can reach the server with no problems. Port security was on but I had long removed it from the port, moved the computer to a different port, cleared port security from the port as well.  A different computer was used and still same results! When the computer is connected to some other location on the network(on a different access switch), it functions just fine!   I have done all but reset the switch. Does anyone have any idea of what I can possibly be looking at?