PageRequestManagerServerErrorException 500

I get this error, Sys.WebForms.PageRequestManagerServerErrorException: An unknown erro occured while processing the request on the server.  The status code returned from the server was: 500, when I click a command button on a grid row.  

I can not reproduce the error in VS with IE 7, but the client gets it in IE 6 and IE 7.  I am debugging with the same database as the client and entering the same values in the form.  I do not get the error.

Is this a data validation issue?  Should I implement RequestValidation=False?
Why can't I reproduce it?

Thanks,
Glenn
GlennHoldenAsked:
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GiftsonDJohnCommented:
It is not a validation issue. It is the exception thrown by the server. Please debug the row command event of the grid if you are not explicitly using any click event on the button. If you are using an event explicitly on the command button, debug the button click event of the command button.
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cdaly33Commented:
What does the data look like that the client is trying to enter in?  It could be a validation issue.
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GlennHoldenAuthor Commented:
The only unusual character is a forwardslash contained in a textbox. As in "07/08 blah blah."
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GlennHoldenAuthor Commented:
I am unable to reproduce the issue in dev environment.  I am hooked (by VPN) to customer's database so I don't know what is different.
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GlennHoldenAuthor Commented:
I have determined the error is occuring when I refer to a session variable in my code-behind.  Still not sure why.
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