Shares unavailable on 2008 server

I have a new server in a site that intermittantly dissapears off the network.  This is the only server in this domain so it is the DC as well as the file server, DNS, DHCP etc.  Approximately once a week I get a call from someone saying that they can't connect to their F: drive which is mapped to a share on this server.  They have internet access and email (which is hosted off site), but can't connect to their file server.  I can log into the server from outside and can browse to any of the workstations and there are no performance issues or events logged.  I'm at a loss where to look for problems.

Thanks,

Glenn
SpyderGAsked:
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mkriszCommented:
Could you be more specific pelase about your network? How many switches / routers are on that network? (the first thing is I think about is a wrong router port). You should instruct your users who have this problem to traceroute the destination server. Then we will know more about where the packets being lost.
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SpyderGAuthor Commented:
This is a very simple network.  There are 7 PCs of which only 4 access the server.  The others only use internet and local drives and have no issues.  There is a router to the internet and one layer 2 switch.  The problem is definitely server related and not network as a reboot of the server fixes it every time.
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