Invaild drive message when Installing a program on SBS Server 2003

I 've had some problems with an upgrade to our practise management software. When I run the install it goes through the process of setting up for install but then gives the message; 'Error 1327. Invaild Drive : S:\'.
I have contacted the practise management software company and they suggested that I map one of drive letters to 'S' and 'try' that. I, on the other hand, don't really like the sound of doing that, I would prefer to know why it is returning this message first place.
The update came on a CD and that was the recommended place to install from. I have also tried copying the the data to a folder on the server and installing from there, but with no luck, I get the exact same error message.
Any suggestions? Could the problem be in the writing of the update it self.
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Click Start, and then click Run.

In the textbox, type regedit, and then click OK.

In Registry Editor, locate the following registry key:

HKEY_CURRENT_USER\Software\Microsoft\Windows\CurrentVersion\Explorer\Shell Folders

In the right pane, note the values in the Data field of each entry. If any value contains a drive that is not correct for your computer, right-click the entry, replace the invalid entry with the correct drive letter and subdirectory if necessary in the Value data box, and then click OK.  (make sure you dont change anything that doesnt need to be)

Repeat steps for each entry whose Data value contains an incorrect drive.

Check out these keys also

HKEY_CURRENT_USER\Software\Microsoft\Windows\CurrentVersion\Explorer\User Shell Folders


HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows\CurrentVersion\Explorer\Shell Folders

HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows\CurrentVersion\Explorer\User Shell Folders

Close Registry Editor. Reboot&..Good Luck!

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