Redhat linux

The CPAN will install all needed perl modules, following the dependencies for each.  But if a particular perl module requires a non-perl package to be installed through YUM, it will not automatically take care of it.

I'm not as familiar with YUM, but I use apt, and I'm guessing YUM is similar.  If so, when you select a package to add, it'll add all dependencies.  So, as long as ptkdb is an available package, you should be able to install it.  To search, run the command:
    yum search ptkdb
If you also want Tk, search for it with:
    yum search perl-Tk

Use this command to install packages with yum, you have to run either search or install to find out if the package is offered by RedHat and supported. The worst thing will happen is it will come back saying the package was not found, in which case you have to download the RPM with other dependencies or compile everything from the source.
Also, if the ptkdb package is found, it will automatically install needed dependencies, thus you would not need to use yum on Tk ....etc.

Good Luck!

yum install ptkdb*

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Were you able to install ptkdb?