How to properly remove user profiles in Vista system?

This is a Windows 2003 AD domain. A vista system was found with multiple user profiles, few with the sizes in gigabytes dimensions. I tried to delete directly from C:\Users folder, but to no avail.

Any proper method to share with?
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DonNetwork AdministratorCommented:
Try the policy setting:
Computer configuration-->Administrative templates-->System-->User Profiles-->Delete
user profiles older than a specified number of days.
Right mouse click the "COMPUTER" icon on your desktop > Select Properties> select Advanced system Setting> select the advanced tab > select settings next to User Profiles> highlight the user profile you wish to delete and then select delete.
DonNetwork AdministratorCommented:

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Windows Vista

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