Every now and then, my system bogs down to a crawl, and I find that my memory usage is at 99%. This seems to happen while I have a few apps open and am employing some memory intensive tasks. Closing all of the open user applications does not free up memory. Sometimes, when this occurs, an application on a networked machine is retrieving very large files from the problem machine. Only a reboot seems to resolve the issue. I'm running Vista 64, SP-2, with 16GB RAM, DDR2 PC2-6400 ECC, on a SUPERMICRO X7DWA MB. I attached a screem shot that provides a list of most of the processes.