is it safe to run chkntfs command while system is running (not at startup) to check the system health?

Hi all,
Is it safe to run chkntfs command while system is running (not at startup) to check the system health? does it cause any problems or system hangs? i got the following error message (just once)on one of my critical systems, and i don't want to reboot the system as possible.

Event Type:      Error
Event Source:      Ntfs
Event Category:      (2)
Event ID:      55
Date:            7/15/2009
Time:            9:05:34 AM
User:            N/A
Computer:      XYZ
Description:
The file system structure on the disk is corrupt and unusable. Please run the chkdsk utility on the volume SYSTEM.

For more information, see Help and Support Center at http://go.microsoft.com/fwlink/events.asp.
Data:
0000: 0c 00 04 00 02 00 52 00   ......R.
0008: 02 00 00 00 37 00 04 c0   ....7..À
0010: 00 00 00 00 02 01 00 c0   .......À
0018: 00 00 00 00 00 00 00 00   ........
0020: 00 00 00 00 00 00 00 00   ........
0028: 17 0b 14 00               ....    
ksisletimAsked:
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QlemoBatchelor, Developer and EE Topic AdvisorCommented:
It is safe to do so. You can always perform a chkdsk without switches, which does only tests.

chkdsk /f or /r however (which perform repair actions) need to access the partition exclusively, and depending on the partition type (system, pagefile, data) this can't be done without rebooting.
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