mail.que file goes from 0 to 4.9gig in about 40 minutes

This is quite baffeling, it started yesterday, but the mail.que file fills up to 4.9gig then crashes the MSExchangeTransport service.  This is a very small orginization, maybe 40 mailboxes all together.  The queue viewer is empty most of the time during this 40 minutes, there are a few messages going in and out, but nothing major.  

This is the process I follow to bring the Transport service back online:

http://technet.microsoft.com/en-us/library/bb124343.aspx

I was cirious, so I pulled the internet connection for about 5 minutes, and during that time the mail.que file was still constantly increasing.

Also, the edgetransport service is going crazy as well. (see screen captures 3 minutes apart)

Attached is my edgetransport.exe.config

Aside from spending the long weekend rebuilding the queue file every 40 minutes, what can I do?

<configuration>
  <runtime>
    <gcServer enabled="true" />
    <generatePublisherEvidence enabled="false" />
  </runtime>
  <appSettings>
    <add key="AgentLogEnabled" value="true" />
    <add key="ResolverRetryInterval" value="30" />
    <add key="DeliverMoveMailboxRetryInterval" value="30" />
    <add key="ResolverLogLevel" value="Disabled" />
    <add key="ExpansionSizeLimit" value="1000" />
    <add key="MaxIdleTimeBeforeResubmit" value="12:00:00" />
    <add key="MailboxDeliveryQueueRetryInterval" value="00:05:00" />
    <add key="QueueGlitchRetryInterval" value="00:01:00" />
    <add key="QueueGlitchRetryCount" value="4" />
    <add key="PFReplicaAgeThresholdHours" value="48" />
    <add key="DeferredReloadTimeoutSeconds" value="5" />
    <add key="MaxDeferredNotifications" value="20" />
    <add key="MaxQueueViewerQueryResultCount" value="250000" />
    <add key="RoutingConfigReloadInterval" value="12:00:00" />
    <add key="DumpsterAllMail" value="false" />
    <add key="DumpsterAllowDuplicateDelivery" value="false" />
    <add key="DumpsterDeletionDelayAfterStartup" value="00:02:00" />
    <add key="DatabaseCheckPointDepthMax" value="20971520" />
    <add key="DatabaseMaxCacheSize" value="134217728" />
    <add key="DatabaseCacheFlushStart" value="3" />
    <add key="DatabaseCacheFlushStop" value="5" />
    <add key="QueueDatabaseBatchSize" value="40" />
    <add key="QueueDatabaseBatchTimeout" value="100" />
    <add key="QueueDatabaseMaxConnections" value="4" />
    <add key="QueueDatabaseLoggingFileSize" value="5242880" />
    <add key="QueueDatabaseLoggingBufferSize" value="524288" />
    <add key="QueueDatabaseMaxBackgroundCleanupTasks" value="32" />
    <add key="QueueDatabaseOnlineDefragEnabled" value="true" />
    <add key="QueueDatabaseOnlineDefragSchedule" value="1:00:00" />
    <add key="QueueDatabaseOnlineDefragTimeToRun" value="3:00:00" />
    <add key="QueueDatabasePath" value="d:\queue" />
    <add key="QueueDatabaseLoggingPath" value="d:\queue" />
    <add key="IPFilterDatabasePath" value="C:\Program Files\Microsoft\Exchange Server\TransportRoles\data\IpFilter" />
    <add key="IPFilterDatabaseLoggingPath" value="C:\Program Files\Microsoft\Exchange Server\TransportRoles\data\IpFilter" />
    <add key="TemporaryStoragePath" value="C:\Program Files\Microsoft\Exchange Server\TransportRoles\data\Temp" />
    <add key="EnableResourceMonitoring" value="false" />
    <add key="ResourceMonitoringInterval" value="00:00:02" />
    <add key="PercentageDatabaseDiskSpaceUsedHighThreshold" value="0" />
    <add key="PercentageDatabaseDiskSpaceUsedMediumThreshold" value="0" />
    <add key="PercentageDatabaseDiskSpaceUsedNormalThreshold" value="0" />
    <add key="PercentageDatabaseLoggingDiskSpaceUsedHighThreshold"
      value="0" />
    <add key="PercentageDatabaseLoggingDiskSpaceUsedMediumThreshold"
      value="0" />
    <add key="PercentageDatabaseLoggingDiskSpaceUsedNormalThreshold"
      value="0" />
    <add key="PercentagePrivateBytesUsedHighThreshold" value="0" />
    <add key="PercentagePrivateBytesUsedMediumThreshold" value="0" />
    <add key="PercentagePrivateBytesUsedNormalThreshold" value="0" />
    <add key="VersionBucketsHighThreshold" value="200" />
    <add key="VersionBucketsMediumThreshold" value="120" />
    <add key="VersionBucketsNormalThreshold" value="80" />
    <add key="PercentagePhysicalMemoryUsedLimit" value="94" />
    <add key="DehydrateMessagesUnderMemoryPressure" value="true" />
    <add key="VersionBucketsHistoryDepth" value="3" />
    <add key="PrivateBytesHistoryDepth" value="30" />
    <add key="CrashOnStopTimeout" value="false" />
    <add key="DnsFaultTolerance" value="Lenient" />
    <add key="PriorityQueuingEnabled" value="false" />
    <add key="MaxPerDomainHighPriorityConnections" value="3" />
    <add key="MaxPerDomainNormalPriorityConnections" value="15" />
    <add key="MaxPerDomainLowPriorityConnections" value="2" />
    <add key="HighPriorityMessageExpirationTimeout" value="8:00:00" />
    <add key="NormalPriorityMessageExpirationTimeout" value="2.00:00:00" />
    <add key="LowPriorityMessageExpirationTimeout" value="2.00:00:00" />
    <add key="HighPriorityDelayNotificationTimeout" value="00:30:00" />
    <add key="NormalPriorityDelayNotificationTimeout" value="4:00:00" />
    <add key="LowPriorityDelayNotificationTimeout" value="8:00:00" />
    <add key="MaxHighPriorityMessageSize" value="250KB" />
    <add key="ByteEncoderTypeFor7BitCharsets" value="1" />
  </appSettings>
  <system.net>
    <connectionManagement>
      <add address="*" maxconnection="10" />
    </connectionManagement>
    <defaultProxy>
      <proxy usesystemdefault="false" autoDetect="true" />
    </defaultProxy>
  </system.net>
</configuration>

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