Upload Excel Kill Excel Process

I have and upload button on a web page that uploads an excel document and saves it to a particular location.  That works fine.  Once it saves it to a particular location I have to open up that file and then move it to a SQl database table.  that works fine as well, but what I am noticing is that once I upload the file the Excel process stays open and no matter what I do I can not seem to delete/kill that process.  i also have idenity impersonate =true in the web.config file.  i have tried almost every solution that google has to offer but nothing seems to work.  Please someone help.  Thanks.