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GerardeDelaneyFlag for United Kingdom of Great Britain and Northern Ireland

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Programs very slow to load when double click document directly. OK if opened within application

I have two XP Pcs that have suddenly developed this problem. it's happening for all applications.  If I click on ,lets say a pdf, nothing happens for about 45 seconds, then the PDF will open. This happens for local PC documents as well as those on network shares. If I open Adobe Reader first and then open the pdf, it opens instantly. Nothing has changed on these two PCs, no updates, new hardware or software, nothing. If I disable the network connection, program and document load instantly. I have noticed also that in Tools ..Folder Options, if I click the File Types tab the 'searchlight' takes about 45 seconds to display the file associations. All of the Associations are correct, and the DDE options are the same on these PCs  as on the working PCs.

Gerarde
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johnb6767
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There are no disconnected network drives. The PC finds all network resources quickly. When I double click on a file there is no increase in CPU activity until the program actually starts to load (45 seconds or so) and the file is then scanned by AV. Anti Virus reporting file system clean. If I disconnect the network cable or disable the network connection, local files will load instantly on double-click.
I followed the 'Clean Booting Windows' article before I posted here.
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Thanks for the suggestion Johnb. Disabled the Anti Virus scanning. Ran Procmon. No obvious errors looking for programs or processes.
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We are not using any Symantec / Norton Products. i've disabled the AV (Sophos) but that made no difference. I've looked at the support article but the symptoms were not really the same. When I open the task list, there is no CPU activity at all during the 45 seconds between double clicking the document and the programs loading and being displayed.
We do have HP printers. I have removed them. In fact I have removed all printers from the PC but there has made no difference unfortunately.
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Jonvee

Ok, thanks...
Well, you scanned for viruses, how about Malware?
If not scanned i recommend downloading & updating Malwarebytes anti-Malware, from here:
http://www.malwarebytes.org/mbam.php
When updated, reboot into Safe Mode by depressing F8 and run a scan.

Tutorial available, if you require >
http://www.bleepingcomputer.com/forums/lofiversion/index.php/t169669.html
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Looking at the obsolote network shares. Though there were none in the ' my network places ' area, there were certainly some located within the HK_Classes_Root. Will weed them out and give it another go.
 
It was difficult to find a definitive answer to this question as there are several problems that might show the symptoms that I was experiencing.
I found a solution to my problem. Thanks to Jonvee I found that there were several references in the HK_Classes_Root registry hive to an old server that these two PCs used to connect to a couple of years ago. Had to use a freeware program called RegScanner and searched for references to UNC paths (beginning with \\) to shares that may no longer exist. Realised from the list presented to me that the server had recently been stripped of much of its data (an consequently its shares, and had been given a different IP address.

Thanks to everyone who has tried to help with this.
Thanks for the feedback....glad you've resolved it.