Cannot run OPSMGR2007R2EVAL.exe. Get error when trying to open this file

My OS is Windows Server 2003 R2 SP2
The file is installed locally on the E drive.Loads of disk space. Good spec server (Dell) Logged on as administrator

Downloaded this directly from Microsoft downloads (for the 3rd time as i first thought it was a corrupt download)
Error is "Windows cannot access the specified device, path, or file. You may not have the appropriate permissions to access the item"
I am admin and the NTFS ACLs are all correctly set

IE enhanced security is off. DEP was on but i have turned it off. Have downloaded and run many other .exe files without problems

Can anyone help?? I have hardcore debugging tools at my disposal to examine the exe file if need be but no experience using them (visual studio 2005 etc)
IzattafactAsked:
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IzattafactAuthor Commented:
quick update - this file runs on other servers in the same domain with the same logon credentials
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IzattafactAuthor Commented:
running it on another server shows that the exe is just a self extracting archive. extracting it elsewhere and will run the setup after extraction
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