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Well assuming you have the port forwarding setup properly and RPC configured on the server, it should work fine. The 2 best articles on the internet on how to look for connectivity issues and how to set RPC up is below. Please carefully read the instructions without skimming through it. <br />
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<a href="http://www.petri.co.il/testing_rpc_over_http_connection.htm" rel="ugc">http://www.petri.co.il/testing_rpc_over_http_connection.htm</a><br />
<a href="http://www.petri.co.il/how-can-i-configure-rpc-over-https-on-exchange-2003-single-server-scenario.htm" rel="ugc">http://www.petri.co.il/how-can-i-configure-rpc-over-https-on-exchange-2003-single-server-scenario.htm</a>
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Well assuming you have the port forwarding setup properly and RPC configured on the server, it should work fine. The 2 best articles on the internet on how to look for connectivity issues and how to set RPC up is below. Please carefully read the instructions without skimming through it.

http://www.petri.co.il/testing_rpc_over_http_connection.htm [http://www.petri.co.il/testing_rpc_over_http_connection.htm]
http://www.petri.co.il/how-can-i-configure-rpc-over-https-on-exchange-2003-single-server-scenario.htm [http://www.petri.co.il/how-can-i-configure-rpc-over-https-on-exchange-2003-single-server-scenario.htm]

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I have three computers that will not connect to a SBS 2003 Server using the HTTP Proxy. I have a valid SSL and tested it against OWA which works fine, no certificate errors. Because the three computers won't connect it apppears the problem is on the server and not with Outlook. Clients are using Outlook 2003 and 2007. Server is Exchange 2003 SP2<br />
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I notice in exchange I do not have the option to select RPC-HTTP front end server. Is this why clients can't connect Outlook to Exchange over the internet? 
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I have three computers that will not connect to a SBS 2003 Server using the HTTP Proxy. I have a valid SSL and tested it against OWA which works fine, no certificate errors. Because the three computers won't connect it apppears the problem is on the server and not with Outlook. Clients are using Outlook 2003 and 2007. Server is Exchange 2003 SP2

I notice in exchange I do not have the option to select RPC-HTTP front end server. Is this why clients can't connect Outlook to Exchange over the internet? 

Exchange RPC-HTTP, Outlook unable to connect to exchange using HTTP

Exchange is the server side of a collaborative application product that is part of the Microsoft Server infrastructure. Exchange's major features include email, calendaring, contacts and tasks, support for mobile and web-based access to information, and support for data storage.

Exchange

Microsoft Outlook is a personal information manager from Microsoft, available as a part of the Microsoft Office suite. Although often used mainly as an email application, it also includes a calendar, task manager, contact manager, note-taker, journal, and web browser.