Open Port 443 to allow iPhone and Exchange Server 2003 to talk?

I have been reading the posts trying to resolve issue with iPhone.  We have 4 employees with them  2 phones work fine with Exchange and Outlook.  The other 2 setup fine but then cannot receive emails.  Folders are all there just won't connect to server.  Why???  I found some other question/answers on here.  Ran one of the tests but don't know what to do now.

Results were:
      Testing Exchange ActiveSync
       Exchange ActiveSync test Failed
       
      Test Steps
       
      Attempting to resolve the host name mail.lease-sped.org in DNS.
       Host successfully resolved
       
      Additional Details
        IP(s) returned: 216.125.46.165
      Testing TCP Port 443 on host mail.lease-sped.org to ensure it is listening and open.
       The specified port is either blocked, not listening, or not producing the expected response.
        Tell me more about this issue and how to resolve it
       
      Additional Details
        A network error occurred while communicating with remote host
Exception Details:
Message: No connection could be made because the target machine actively refused it 216.125.46.165:443
Type: System.Net.Sockets.SocketException
Stack Trace:
at System.Net.Sockets.TcpClient.Connect(String hostname, Int32 port)
at Microsoft.Exchange.Tools.ExRca.Tests.TcpPortTest.PerformTestReally()


Do I need to open this port and if so how?  Why does it work fine for half the phones (identical and updated software wise).  Any help greatly appreciated.
mclghln1Asked:
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Alan HardistyCo-OwnerCommented:
If you are using SSL, then you need to open port 443 - if not, then only port 80.
Ideally you should be using SSL and thus will require prot 443 open.
Please have a read of my Exchange 2003 / Activesync article for details of the required settings etc:
http://www.experts-exchange.com/articles/Software/Server_Software/Email_Servers/Exchange/Exchange-2003-Activesync-Connection-Problems-FAQ.html 
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mclghln1Author Commented:
so user that was having problems had other iphone problems and they replaced her phone.  i tried setting up again but had same problems.  her calendar is actively syncing and her email folders are there.  she just gets error message when trying to check for new emails.  i deleted the account and added my work account and it worked just fine.  so assuming now that my problem is in her user profile?  any ideas where to look.  close look at properties of her user name show same things as mine.  any ideas would be very helpful.

thanks
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Alan HardistyCo-OwnerCommented:
Please look through my article - check your settings as per my article, run the tests and report back any errors that are not resolved by following the relevant errors section in my article.
Thanks
Alan
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mclghln1Author Commented:
it just started to work.  i can't explain it.  didn't make any changes.  spoke with apple tech and they just laughed when i said windows exchange and that it sometimes work and sometimes doesn't.
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Windows Server 2003

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