Sharepoint incoming email problem

We have a customer with a Sharepoint site which has been receiving email normally for more than a year.  Nothing on the server has been changed, but today users began reporting that emails to the site are being rejected with the error 550 5.7.1 Unable to relay for <address>.

I've tried restarting the SMTP service, but this didn't solve the problem.

It is a Windows 2008 Server running SharePoint Services 3.0.
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johnny_the_knifeAuthor Commented:
I think I may have resolved this.  The SMTP server didn't have an email domain alias configured for the address space to which the sharepoint emails are sent.  I added this and it seems to be working.

I have asked the customer to test and I will report back later today.
It might very well be due to a hotfix / patch or automatic update... So "something" has probably been "changed" under the hood.

Have you checked your SMTP service's relay settings?

johnny_the_knifeAuthor Commented:
The relay settings appear normal, however, in the event log I am seeing the following error:

Message delivery to the remote domain <domain> failed for the following reason:  unable to deliver the message because the destination address was misconfigured as a mail loop
This question has been classified as abandoned and is being closed as part of the Cleanup Program. See my comment at the end of the question for more details.
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