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2008 sbs frequent loss of connection to exchange

I am running a 2008 SBS server and all the users are experiencing a frequent loss of connection to the server. Reconnection occurs in a few seconds but it is very annoying.

Is there any way to stop this?
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Lacretta Incorvaia
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MSExchange error 12014 something about a certificate for SMTP. This is new I will look into it today.

Server is fully patched and updated.
Sounds good.  Here are a couple of resources for that particular error code: http://technet.microsoft.com/en-us/library/bb510128(EXCHG.80).aspx; http://support.microsoft.com/kb/555855.

Keep us posted,
LJ
In addition  to the suggestions made here I had a misconfiguration of the Hub transport internet receive configuration. I had the wrong URL configured. Between the two the problem is fixed.