XP clients disconnect from Windows 2008 file shares

I have a customer that has a Windows 2008 file server that every couple of hours disconnects XP and Windows 2003 servers. When the problem occurs mapped drives are no longer accessible and you can't access shares via UNC either. The server can be pinged though. Vista and Windows 2008 servers are not affected. Any ideas?  
SSsourceAsked:
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snafumasterDirector of Information TechnologyCommented:
Does this happen in relation to inactivity?
Does the client have enough CALs for the number of Clients?
Is this a domain enviroment?
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SSsourceAuthor Commented:
No,  it has nothing to do with inactivity. When it happens all XP computers and 2003 servers lose access to all the shares on the 2003 servers, but the other 2008 servers and VIsta and Windows 7 clients still have access to the shares. It is in a domain, and there are enough CALs.
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snafumasterDirector of Information TechnologyCommented:
OK, that ules a few things out.  Now I'm thinking about the similarities between XP and 2003 in comparison to to Vista, 7 and 2008. The first thing that comes to mind is IPv4 and IPv6.  Are you using IPv6?
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SSsourceAuthor Commented:
Yes, IPV6 is enabled.
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snafumasterDirector of Information TechnologyCommented:
I wish I were a bit more up to date with IPv6 to assist more.  I think you are going to find that being the place to look for resolution though.  Take a look at http://www.techsutram.com/2009/03/differences-ipv4-vs-ipv6.html  It shows a nice comparison between the two.  This is indeed a quirky issue!
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SSsourceAuthor Commented:
Update.....I disabled IPV6 on the file server and so far the issue hasn't come back. Previous to this, the issue would occur every few hours, so I am hopeful this took care of it.
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snafumasterDirector of Information TechnologyCommented:
That is great news!  Let us know!
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snafumasterDirector of Information TechnologyCommented:
It looks like the OP like my fix but failed to award points.
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