Application not found

I have a user that can log-in and get to the net. When she tries to open an application, control panel or anything else it says, "application not found". If she logs onto the computer in Safe Mode, it works fine. When she logs onto another computer everything works fine. We are on a network. If anyone else logs onto her computer, everything works fine. What I've tried to fix the problem:

scan disk
cleaned reg with CCleaner
Virus scan
spyware scan
uninstalled Office 2007 and re-installed
disk clean-up

Anything else I can try before I reinstall Windows?

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just creat a new profile for the user and copy all info from one profile to the next, then delete the old profile.
Combofix from (the link to the file is here)

Make sure you do virus scans in safe mode (repeatedly press F8 after you see the POST screen). Try Spybot search and Destroy

and don't forget :

Hope that helps!
There may be a file association issue. Use the EXE File Association Fix (assuming your using XP):
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If the file associations have been destroyed; you can use this guide to re-associate them.
Check this value.....


The value should be "exefile".....

Could explain why it only happens to one user. The .exe reg files dont address this one......
Try removing the existing association to that file type, then redo the association. Then try opening the app again and see if it works.
Did you/user try installing printer lately if so uninstall the printer and try it again . Also suggested above is to delete a old profile, instead of deleting profile rename them and have the user log back in, windows will create a new profile for user.

klingon4uAuthor Commented:
You were the first to reply and your solution worked right off the bat. Thank you!
Did you verify the key above that I posted? Id be curious to know if it was correct, as thats the only USER setting for file extensions.....

Curious to know if something else in the user's profile is jacking with these now.....
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