hotfix install in a live server environment

I'm about to install the following hotfix on my server 2008 which consists of Exchange 2007 also.

It should be alright to install this in a live server environment right?
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should be OK, the server might prompt for a reboot after the install though if files are in use. so you may want to wait unti after work hours or do it at lunch time.

Make a full backup of your server first or if one happened last night then that is fine.

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       you can install hotfix for Backup Exec 12.5 in a live server. It will not create any problem.
But schedule should not run at the Time.
- Administrative privileges are required to install this service pack.

Post Requisites
- A full backup is recommended after installing this hotfix.
- The IDR recovery media (the ISO created through the IDR Wizard) needs to be recreated after installing this hotfix.
- Remote Agent for Windows Servers will need to be updated after installing this hotfix.
- Remote Agent for Linux/Unix/Macintosh Servers (RALUS/RAMS) will need to be updated after installing this hotfix.
- Desktop/Laptop clients will need to be updated after installing this hotfix.
please See the below link before install:
Please reply.  
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