Thanks for any help here, as I need to check into experience with autoresponders. Native Exchange 2007 methods and 3rd party are fair game here. We need to have autoresponders on several e-mail addresses. I know we could do these with Out of Office, or with Transport rules. But the deal is that ideally we need them to be able to turn on and off automatically, at certain times of day, every day. (So, basically looking at server-based.) And we need to be able to change them from time to time, so it would be nice to preserve multiple autoresponders and just turn one off and another on for the same address. So, we need some strong autoresponder functionality here... maybe 3rd party. People have mentioned Exclaimer but at first glance, it doesn't seem like it is "primarily" an autoresponder product, although I'm willing to be corrected on that. Comment welcome.