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It can be done through GPO for IE..
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How to block users from change Proxy sitting in internet explorer and Mozilla Firefox ?
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How to block users from change Proxy sitting in internet explorer and Mozilla Firefox ?

How to block user from change Proxy

Operating system security (OS security) is the process of ensuring OS integrity, confidentiality and availability. OS security refers to specified steps or measures used to protect the OS from threats, viruses, worms, malware or remote hacker intrusions. OS security encompasses all preventive-control techniques, which safeguard any computer assets capable of being stolen, edited or deleted if OS security is compromised, including authentication, passwords and threats to systems and programs.

OS Security

Windows Server 2003 was based on Windows XP and was released in four editions: Web, Standard, Enterprise and Datacenter. It also had derivative versions for clusters, storage and Microsoft’s Small Business Server. Important upgrades included integrating Internet Information Services (IIS), improvements to Active Directory (AD) and Group Policy (GP), and the migration to Automated System Recovery (ASR).

Windows Server 2003

Web browsers are applications used primarily to display documents, files and media from the Internet, identified by a Uniform Resource Identifier (URI) that can be a page, image, video or other file. Some browsers require the use of add-ons or extensions to safely render the information they receive; others have systems built into them to perform the same functions.