Although this issue appears to only affect one client, it is something I am determined to fix. I have a clilent who can access the Citrix web interface and launch one of the available applications (OWA) but not the other (a medical application). After clicking the medical application icon in the WI, a pop-up box brienfly appears, showing an attempt to launch/open the 'launch.ica' file, and then diaappears. I have attached a screenshot for your review. So far, I have tried deleting browser cache, history, etc. and checked Java is installed, updated, and working as expected. Client is running Windows 7 64Bit and IE 8. What could be causing this? Thanks for any insight!