Configure Exchange 2003/Outlook 2007 to auto reject incoming email to an email account

even I'm not sure how to configure the pop up message you mention. However what I could suggest is to create a rule to this mailbox such that any email coming to this mailbox should get an Auto reply with "please do not reply call this number ....."

check the below link to configure that kind of rule
http://www.timeatlas.com/email/outlook/create_auto_reply_emails_with_outlook_rules_a_template

The email address I am using is donotreply@mydomain.org and staff uses this email account to send message to thousands of clients. Even though the email stated please do not reply this email the clients sent their questions  to donotreply email account anyway. I was wonderting if Exchange server  can physically reject the messages coming to donotreply account.

maytrix's solution is the easiest one to implement.
For the pop-up thing, you need to code some VBA

You can not create scripts that will run popups on other peoples computers. How do you think viruses spread?  Imagine if everyone was allowed to send you emails that contained scripts in them ;)

@Sunnyc7
Would you like to explain how his VBA code will get to run on thousands of clients computers? Hotmail accounts? gmail accounts?
It is not possible to do. end of story

I withdraw that :)
@ figured out my mistake when I saw your post on how viruses spread -- nightmare to maintain this.

Withdrawl granted ;)

Thank you ^:)^

I am sorry I didn't make my question clear. What I really perfer is a way to reject any incoming email to donotreply account.

Use my solution and they will get an NDR if they reply to the message, as long as you specify an email that does not exist.

You can setup an Out of Office for the account with your DO not Reply message, or have it handled through NDR's / DSN status code.

It's much easier to do this from Exchange 2007 using transport rules.
I will wait for others to post..

when the clients try to reply not only they see please do not reply this email but physicaly has deliverly failure as well.

Check Sembee's reply here
https://www.experts-exchange.com/questions/22959903/Exchange-2003-No-Reply-Email.html

Are you trying to configure a noreply@domain.com - and use that to send email messages.
Kinda like EE's message alerts when someone posts to a message ?

Use an email account that for example is called Sendout@mycompany.com BUT set the reply-to adress to DONOTREPLY@mycompany.com.
As there is NO account called DONOTREPLY@mycompany.com then your exchange will just send an NDR, assuming you have NDR's configured, and that in itself is bad practice......
 

With my method, they will receive an NDR saying the address did not exist.  There is no way that you can get them to see anything else at their end, other then the content you add to the original message.

so if you include in the message "REPLIES TO THIS MESSAGE WILL BE REJECTED" then they'll see that text only as they read the message.  A popup will not work.

But everyone talks of NDR's....
Do you all seriously send out an NDR to every spammer that is phishing for email accounts/AD account names???

Yeah, after I posted the last message I saw the NDR comments.  That's a good point as most people don't do it these days.

Having it reply to a valid address would work with an Auto-reply set on that account.  Many places these days send out message though and state replies will be rejected, so I really don't see an issue in just stating it clearly in the message and leaving it at that.

neilsr :)
i know where you are going with this...Very good point.

Will wait for everyone to post their thoughts.

I like Neilsr's way of doing that. set up regular account but set up reply to address dornotreply@ company.org which is not existed. Very good!  I just wish the clients not only receive delivery failue but they will see  the message if you have questions please call ...... I guess I am too greedy!

Thank you for your gernerous help!

WOW!
I normally expect to get points when i am told by the questioner that he likes my answer!!

lgallion - I think you incorrectly marked the first answer as correct.

Please select neilsr's answer and assign points to that.

If you need help with this, you can click on Request Attention link on top of the page and have a moderator do this for you.

And why was his answer better then mine?  It's the same thing.   You even said mine was the easiest to implement ater I posted it :)  Same answer, I posted the respone first, seems logical I should get the points.  At best I could see them being split.