I have been fighting a problematic issue for months. We have a workstation that will become "non responsive" to the mouse. The cursor will move and you can click on the start menu, but you are unable to open programs, right click, etc. You can ctrl-alt-delete and click on the Task Manager but it will not load. We have formatted the drive and totally rebuilt the system multiple times and still find ourselves to this point after a few weeks or months. I am not sure if there is a windows update that causes this? The only resolution is to reboot the computer by holding down the power button. This is a pretty simple setup for installations. Base windows xp with SP3, AVG 9 internet security, and a Philips handheld voice recorder running .net 2.0 transfer software from Fusion for healthcare dictations. I have tried troubleshooting by uninstalling app by app but still have this issue. Has anyone encountered this before? Maybe a registry issue?