the transport failed to connect to the server

I am getting "the transport failed to connect to server" im my asp.net application.  I am not sure what is causing this after 2 years of running smoothly.  Basically the web app is a helpdesk ticket system.  it sends an email to the pc tech.

Exact error:
The transport failed to connect to the server.

Description: An unhandled exception occurred during the execution of the current web request. Please review the stack trace for more information about the error and where it originated in the code.

Exception Details: System.Runtime.InteropServices.COMException: The transport failed to connect to the server.


Source Error:


Line 238:SmtpMail.SmtpServer = "10.1.88.34"
Line 239:
Line 240:SmtpMail.Send(mailobj2)
Line 241:
Line 242:
 

Source File: c:\inetpub\wwwroot\helpdesk\Admin\CreateNewTicket2.aspx    Line: 240

Stack Trace:


[COMException (0x80040213): The transport failed to connect to the server.
]

[TargetInvocationException: Exception has been thrown by the target of an invocation.]
   System.RuntimeType.InvokeDispMethod(String name, BindingFlags invokeAttr, Object target, Object[] args, Boolean[] byrefModifiers, Int32 culture, String[] namedParameters) +0
   System.RuntimeType.InvokeMember(String name, BindingFlags bindingFlags, Binder binder, Object target, Object[] providedArgs, ParameterModifier[] modifiers, CultureInfo culture, String[] namedParams) +337
   System.Type.InvokeMember(String name, BindingFlags invokeAttr, Binder binder, Object target, Object[] args, CultureInfo culture) +36
   System.Web.Mail.LateBoundAccessHelper.CallMethod(Type type, Object obj, String methodName, Object[] args) +66
   System.Web.Mail.LateBoundAccessHelper.CallMethod(Object obj, String methodName, Object[] args) +49

[HttpException (0x80004005): The transport failed to connect to the server.
]
   System.Web.Mail.LateBoundAccessHelper.CallMethod(Object obj, String methodName, Object[] args) +99
   System.Web.Mail.CdoSysHelper.Send(MailMessage message) +1738
   System.Web.Mail.SmtpMail.Send(MailMessage message) +351
   ASP.helpdesk_admin_createnewticket2_aspx.Submit_Click(Object Src, EventArgs E) in c:\inetpub\wwwroot\helpdesk\Admin\CreateNewTicket2.aspx:240
   System.Web.UI.WebControls.Button.OnClick(EventArgs e) +111
   System.Web.UI.WebControls.Button.RaisePostBackEvent(String eventArgument) +110
   System.Web.UI.WebControls.Button.System.Web.UI.IPostBackEventHandler.RaisePostBackEvent(String eventArgument) +10
   System.Web.UI.Page.RaisePostBackEvent(IPostBackEventHandler sourceControl, String eventArgument) +13
   System.Web.UI.Page.RaisePostBackEvent(NameValueCollection postData) +36
   System.Web.UI.Page.ProcessRequestMain(Boolean includeStagesBeforeAsyncPoint, Boolean includeStagesAfterAsyncPoint) +1565

 
This is my vb.net code for email:

Dim mailobj2 AS new MailMessage
mailobj2.From = "mmchelpdesk@maimonidesmed.org"

mailobj2.To = ddlTechAssign.SelectedItem.value

mailobj2.Subject = "New Help Desk Request - CaseID#:" + txtCaseID.text
mailobj2.BodyFormat = MailFormat.text
mailobj2.Body = ("Case ID#: " + txtCaseID.Text + " " + Chr(13) + "Date/Time Submitted: " + DateTime.Now.ToString("MM/dd/yyyy hh:mm:ss") + "" + "" + Chr(13) + Chr(13) + "Problem Description: " + Chr(13) + txtProbDetails.text + Chr(13) + Chr(13) + "Ticket Status:" + " " + txtStatus.text + Chr(13) + Chr(13) + "User Contact Details:" + Chr(13) + txtUFName.text + Chr(13) + txtULName.text + Chr(13) + txtDep_Location.text + Chr(13) + txtUPhoneExt.text)


SmtpMail.SmtpServer = "10.1.88.34"

SmtpMail.Send(mailobj2)


Like I said this app was running fine for 2 years straight.  Today I get this error.  Any help would be appreciated.

Thanks,
Kouts1