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Read this:<br />
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<a href="http://www.petri.co.il/windows-server-2008-adprep.htm" rel="ugc">http://www.petri.co.il/windows-server-2008-adprep.htm</a>
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endital1097, I will try your method, even though that sounds excessive. No other way to run exchange prep on the 2008 domain eh? I am going to be introducing exch 2010 soon. Can I/should I run the exch 2010 exchange domainprep on the win2008 domain? and if so, will add the necessary attributes/security to satisfy the exch 2003 domain prep? <br />
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BTW - I ran the exch 2003 domainprep from a workstation (as domain admin) on the 2008 domain, It ran successfully; however, I noticed some of the permissions on the Exchange Enterprise Server group didnt update properly (mainly the write permissions). Is this becouse I didnt run the exch 2003 /domainprep from a Domain controller? 
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Did you wait for ad replication? &nbsp;As long as your account had appropriate permissions it should work<br />

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The account had appropriate permissions; Did I wait for replication before what? 
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this fixed it: <a href="http://technet.microsoft.com/en-us/library/aa997914(EXCHG.80).aspx" rel="ugc">http://technet.microsoft.com/en-us/library/aa997914(EXCHG.80).aspx</a>
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I have a new windows 2008 R2 domain in my forest. I need to run the exchange 2003 /domainprep on that domain; however, I cannot run exch2003 /domainprep on a win 2008 DC. How should I prep this new 2008 domain with exchange 2003 /domainprep.... <br />
<br />
?
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I have a new windows 2008 R2 domain in my forest. I need to run the exchange 2003 /domainprep on that domain; however, I cannot run exch2003 /domainprep on a win 2008 DC. How should I prep this new 2008 domain with exchange 2003 /domainprep.... 

?

exch 2003 /domainprep on win 2008 DC

Exchange is the server side of a collaborative application product that is part of the Microsoft Server infrastructure. Exchange's major features include email, calendaring, contacts and tasks, support for mobile and web-based access to information, and support for data storage.