troubleshooting Question

SPAM how to determine the originator? Exchange 2003

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bmsjeffFlag for Afghanistan asked on
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I have two users who have been recieving messages like these for the last couple of days.  I don't think that they are coming from my server.  How do I determine where they are originating from?  

Your message did not reach some or all of the intended recipients.
      Subject:  smiling to you, dear
      Sent:     9/10/2010 7:33 AM
The following recipient(s) could not be reached: on 9/10/2010 7:33 AM
            There was a SMTP communication problem with the recipient's email server.  Please contact your system administrator.
            < #5.5.0 smtp;550 Requested action not taken: mailbox unavailable (1044235902:3448:-2147467259)>
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