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SBS 2003 Exchange Local Delivery Queue Stuck

I had to do a DR restore of our entire SBS 2003 and since then some users are experiencing difficulties receiving email - both from internal and external sources.

From what I can tell everyone can send email without a problem, both internally and externally. There are just some emails that aren't being delivered internally. For example, I can send an email from my Exchange email to Gmail and all works fine. If I reply to that email, the message never arrives but appears in the Local Delivery Queue.

I've tried running ISINTEG and it returned no errors - I ran it twice.

I've run ESEUTIL /P which also returned no errors.

I'm currently running ESEUTIL /D but it taking forever to complete. It's been running for over an hour and only about 5% is complete!

Assuming none of the above works, is there anything else I can try before going down the Exmerge path of exporting everyone mailboxes, recreating the store and then importing all the mailboxes back in again.

I did have TrendMicro ScanMail for Exchange running but after a bit of research there were suggestions that this could hold up the queue. This has since been removed for the time being but it didn't make any difference. I will reinstall this once Exchange is working properly again.

I've also set logging to Maximum on the MSExchangeTransport service. This returns a lot of errors in the Application Event log:

The following call : EcLocallyDeliverMsg to the store failed. Error code : -1605 (Message-ID <n5U9T3TGJ00000020@server1.int.domain.com.au>). MDB : 030d0d8b-8965-41e1-a2fe-f2e38924510c. FID : . MID : . File : C:\Program Files\Exchsrvr\Mailroot\vsi 1\Queue\NTFS_6ec4c16201cb54d700000034.EML.

Apart from the above mentioned, I don't know what else I can try. Email has been down for almost 4 days now and everyone, including myself is getting very desperate to get it back up.

Any help, advice or otherwise would be greatly appreciated.

Thank you!
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Thanks for the suggestion. As above though, I tried using isinteg to no resolve. I also ran eseutil /p which returned no errors. I started running eseutil /d but it took almost 3 hours to reach about 10% so I cancelled that and remounted the database. Would you believe mail started flowing!!

I'm not sure what the cause was but I will try reinstalling Scanmail shortly and see if that causes any issues.

There is still mail in the Local Delivery Queue that doesn't seem to be moving but apart from that any new emails seem to be flowing through as normal.

I'm also still getting a lot of those errors mentioned above appearing in the Application event log but I can only assume they are referring to the emails stuck in the Local Delivery Queue. If these emails don't clear within the next 12 hours or so, I'm going to delete everything in the queue and see if 1) email continue to get stuck in the queue and 2) if those errors still appear in the Application event log.

I'm currently making a complete backup of the server at the moment so I don't want to change anything until that is complete though - just in case! :)