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Unless you severely trim your database, however, it's doubtful you're going to gain enough space on that drive to give you more than a short time before you'll be in the same situation. What you really need to do is move that database to a larger partition. If you don't have a larger partition on that server, then you need to add disk storage to that server so that you have a partition large enough to accommodate the database and anticipated growth. Unless you have the Enterprise edition of Exchange, the maximum database size is 75GB anyway and you can't add another mailbox store, so you may need to look at upgrading your Exchange version some time soon so that you can allow you database to growth beyond the 75GB limit.