We have Office Professional Plus 2007 SP2 installed on two Windows Server 2008 SP2 remote desktop servers. We also have a MOSS 2007 server. When we try to publish a new document or open an existing document using the URL of a document library with filename we get a message box that says "Path does not exist." When we type a URL with filename in to IE, we get promted to open or save the file. When we select open, the file opens in Word and we are promted to check out the file. We can edit the file and check it back in through Word with no problem. We have the same issue with Excel. Our desktop computers running Office 2007 can publish new documents to document libraries.