Best Way to Block Out of Office Replies When Sending Mass Emails

Well if they don't want any replies they can set the reply to option to a separate mail address.  Or they can generate a temporary rule up that deletes or moves the mail elsewhere.

Option 1:
In the email before being sent
click on the "Options" button.
Check the box that says "Have replies sent to:"  and select a name or null account.
Send message

Options 2:
In the Outlook application
Click Tools -> Rules and Alerts
Click "New Rule"
Click "Next"
Check Only these boxes:
    - Sent only to me
    - With Specific Words in the subject or body
         - Click the link in the "Rule Description" part and type in   Out of Office:
             (Including the ":")
Determine what you want to do with them message
   - i.e. delete move copy etc..
Click "Next"
Add any exceptions that you'd like
Click "Next"
Click "Finish"

If this is Exchange 2007 or 2010 you can create a transport rule to block these.

If it's 2003 server you could try this.

http://support.microsoft.com/kb/825370

Yes I was thinking transport Rule. I'm on 2007.

Would this work.

"From users Inside the organization

"From users inside the organization
and send to users inside the organization
and when the Subject field contains "Out Of Office AutoReply"
silently drop the message"

Is there anything else I should add?

For some reason this is not working. I'm still getting my test accounts out of office emails.

I changed the text pattern to "Out of", and it started to work. Very strange.

Thanks