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Windows Server 2003 experiences serious performance degradation every day at the exact same time

One of my customer has a Windows Server 2003 R2 SP2 64bit with 16GB of RAM.
They have approx 30 users using  SAP business One, most of them accross the network and a few on remote desktop sessions.
The server performance is fine in the mornings, but deteriorates seriously at 2pm everyday.
We have checked all the usual suspects like the task scheduler, software + anti-virus updates to no avail.
We have also tried to spot any processes in task manager with no result.
We have reviewed employee daily routines to establish if anything specific they do could be the cause with no result.
Does anybody know of any software utilities that we might be able to use to assist us with this problem or does anybody have any suggestions in general ?  
Windows Server 2003

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Blu3jeans
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Joseph Daly
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mrroonie
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check times for automatic windows updates or maybe a backup is misconfigured to run at 2pm instead of 2am??
 
nothing in event viewer/applications or /system at 2pm?
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Blu3jeans

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Thank you all for the input.
We have installed Performance Monitor on the server and will switch on monitoring just before 2pm (C.A.T.)  today.
In reply to questions asked :
1) The performance hit is on memory. (The SQL database size is 43GB, the hard drives are SAS and
    the server has dual XEON processors)
2) It's a physical server
3) SQL 2005 SP3 is installed.

We are digesting the other info and will post feedback ASAP
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Blu3jeans

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We have been unable to resolve this issue to date. We found many suggestions helpful and implemented many of them, to no avail though. Thank you all for your input.
Windows Server 2003
Windows Server 2003

Windows Server 2003 was based on Windows XP and was released in four editions: Web, Standard, Enterprise and Datacenter. It also had derivative versions for clusters, storage and Microsoft’s Small Business Server. Important upgrades included integrating Internet Information Services (IIS), improvements to Active Directory (AD) and Group Policy (GP), and the migration to Automated System Recovery (ASR).

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