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I am not familiar with Symantec but with similar applications if the VPN uses a different subnet for VPN clients, which is common, their subnet needs to be added to the security applications &quot;trusted networks (subnets).
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Ps- this would apply to a site to site VPN as well. The remote site's subnet would need to be added. Former comment was directed at software VPN clients.
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The VPN connection itself is connecting fine. It's when they try to browse the network is when it fails.
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If your version of Symantec has any form of firewall, there are blocks on different services. File and Print sharing will only be allowed from the local subnet, you would need to add the VPN user's subnet. This usually doesn't affect the VPN connection itself.
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If that doesn't fix it:<br />
1) SEP 11 does have a firewall (just checked), if enabled can you disable just as a test to determine if it is blocking access, or if it has 'broken' something?<br />
2) What type of VPN are you using? The built-in SBS VPN?<br />
3) Can the VPN clients ping the computer on which the shares are published by IP?<br />
4) If so, can the VPN clients ping the computer on which the shares are published by computer name?<br />
5) If #3 is successful but not #4 can they map a drive by IP? &nbsp;( &nbsp;net use Z: &nbsp;\\192.168.123.123\ShareNam<wbr />e &nbsp;)
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I completely disabled Symantec and still can' get it. But it just came to my attention that whenever the VPN is connected, you cannot browse internet at all. Once you disconnect the VPN, internet works fine. Sooo what does this mean? 
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OK got internet back up and tried pinging the internal and external IP and both timed out.
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Is this the built-in SBS VPN or a 3rd party solution such as Cisco?
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Built-In VPN (The VPN connection through windows)
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As a test, if a user on the LAN connects to the VPN using the server's LAN IP (not external/public IP) can they access the shares?<br />
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Could you also please post the results of ipconfig /all from a problematic remote user while the VPN is connected.<br />

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Just got finished installing Symantec Endpoint 11 on our customer's SBS 2003. Since then, no one remotely can access their mapped drives. They can connect to the VPN fine but when trying to access the mapped drives they a network access error. Help!?
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Just got finished installing Symantec Endpoint 11 on our customer's SBS 2003. Since then, no one remotely can access their mapped drives. They can connect to the VPN fine but when trying to access the mapped drives they a network access error. Help!?

Can't remotely access mapped drives after installation of Symantec Endpoint 11.

Anti-virus software was originally developed to detect and remove computer viruses. However, with the proliferation of other kinds of malware, antivirus software started to provide protection from other computer threats. In particular, modern antivirus software can protect from malicious browser helper objects (BHOs), browser hijackers, ransomware, keyloggers, backdoors, rootkits, trojan horses, worms, malicious layered service providers (LSPs), dialers, fraud tools, adware and spyware. Some products also include protection from other computer threats, such as infected and malicious URLs, spam, scam and phishing attacks, online identity theft (privacy), online banking attacks, social engineering techniques, Advanced Persistent Threat (APT), botnets and DDoS attacks.

Anti-Virus Apps

Small Business Server (SBS) is a line of server operating systems targeted at small businesses by bundling the operating system with a number of other Microsoft products that would normally need to be purchased or licensed separately. The most notable inclusions are Exchange, SQL Server, SharePoint and ISA/TMG (Microsoft's firewall and proxy server).

A virtual private network (VPN) is a network that uses a public telecommunication infrastructure, such as the Internet, to provide remote offices or travelling users access to a central organizational network securely. VPNs encapsulate data transfers using secure cryptographic methods and other security mechanisms to ensure that only authorized users can access the network and that the data cannot be intercepted.